Projects 9005-9007 to full fah

[sryckbos]

An additional three bryostatin projects are moving to full FAH. These projects fold on SMP A4 clients.

Stats:
Project 9005
Deadline: 8.53
Timeout: 3.94
Stats Credit: 213

Project 9006
Deadline: 8.62
Timeout: 3.98
Stats Credit: 216

Project 9007
Deadline: 8.32
Timeout: 3.84
Stats Credit: 207

Project Description:
Bryostatin is a marine natural product that shows promising and unique activity against several diseases (most notably, cancer, HIV/AIDS, and Alzheimer’s). Its main target, protein kinase C (PKC), is a signaling protein central to many cellular functions. In its active form, PKC binds its ligand and is associated with the membrane, but we currently lack structural information about this complex in its membrane microenvironment. The simulations performed on FAH will help to provide a structure to the PKC-ligand-membrane complex. The structure and dynamics of this complex would allow us to understand bryostatin’s binding mode and thus how to modify and tune its structure to improve function or even create new functions as needed for new therapies in the clinic.

All three operating systems should be supported. These jobs will run on systems with 1-24 processors. Please let me know if there are any issues.

Thanks,
Steven