Projects 9002-9004 moving to full FAH
Posted: Mon Oct 28, 2013 5:09 pm
Hey everyone!
Projects 9002-9004 are moving up to full. Here is the project description:
This project folds on SMP A4 clients. It will work on Windows, OS X, and Linux. Will run on 2-24 processors.
Stats:
Project 9002
Deadline: 8.53
Timeout: 3.94
Stats Credit: 213
Project 9003
Deadline: 8.62
Timeout: 3.98
Stats Credit: 216
Project 9004
Deadline: 8.32
Timeout: 3.84
Stats Credit: 207
Project Description:
Bryostatin is a marine natural product that shows promising and unique activity against several diseases (most notably, cancer, HIV/AIDS, and Alzheimer’s). Its main target, protein kinase C (PKC), is a signaling protein central to many cellular functions. In its active form, PKC binds its ligand and is associated with the membrane, but we currently lack structural information about this complex in its membrane microenvironment. The simulations performed on FAH will help to provide a structure to the PKC-ligand-membrane complex. The structure and dynamics of this complex would allow us to understand bryostatin’s binding mode and thus how to modify and tune its structure to improve function or even create new functions as needed for new therapies in the clinic.
Thanks,
Steven
Projects 9002-9004 are moving up to full. Here is the project description:
This project folds on SMP A4 clients. It will work on Windows, OS X, and Linux. Will run on 2-24 processors.
Stats:
Project 9002
Deadline: 8.53
Timeout: 3.94
Stats Credit: 213
Project 9003
Deadline: 8.62
Timeout: 3.98
Stats Credit: 216
Project 9004
Deadline: 8.32
Timeout: 3.84
Stats Credit: 207
Project Description:
Bryostatin is a marine natural product that shows promising and unique activity against several diseases (most notably, cancer, HIV/AIDS, and Alzheimer’s). Its main target, protein kinase C (PKC), is a signaling protein central to many cellular functions. In its active form, PKC binds its ligand and is associated with the membrane, but we currently lack structural information about this complex in its membrane microenvironment. The simulations performed on FAH will help to provide a structure to the PKC-ligand-membrane complex. The structure and dynamics of this complex would allow us to understand bryostatin’s binding mode and thus how to modify and tune its structure to improve function or even create new functions as needed for new therapies in the clinic.
Thanks,
Steven