Project 9000 moving to adv
Posted: Mon Aug 12, 2013 10:15 pm
Hey everyone!
Project 9000 is moving up to advanced. Here is the project description:
This project folds on SMP A4 clients.
Stats:
Deadline: 8.52
Timeout: 3.93
Stats Credit: 213
Project Description:
Bryostatin is a marine natural product that shows promising and unique activity against several diseases (most notably, cancer, HIV/AIDS, and Alzheimer’s). Its main target, protein kinase C (PKC), is a signaling protein central to many cellular functions. In its active form, PKC binds its ligand and is associated with the membrane, but we currently lack structural information about this complex in its membrane microenvironment. The simulations performed on FAH will help to provide a structure to the PKC-ligand-membrane complex. The structure and dynamics of this complex would allow us to understand bryostatin’s binding mode and thus how to modify and tune its structure to improve function or even create new functions as needed for new therapies in the clinic.
Thanks,
Steven
Project 9000 is moving up to advanced. Here is the project description:
This project folds on SMP A4 clients.
Stats:
Deadline: 8.52
Timeout: 3.93
Stats Credit: 213
Project Description:
Bryostatin is a marine natural product that shows promising and unique activity against several diseases (most notably, cancer, HIV/AIDS, and Alzheimer’s). Its main target, protein kinase C (PKC), is a signaling protein central to many cellular functions. In its active form, PKC binds its ligand and is associated with the membrane, but we currently lack structural information about this complex in its membrane microenvironment. The simulations performed on FAH will help to provide a structure to the PKC-ligand-membrane complex. The structure and dynamics of this complex would allow us to understand bryostatin’s binding mode and thus how to modify and tune its structure to improve function or even create new functions as needed for new therapies in the clinic.
Thanks,
Steven