Welcome back, BornAgainPagan.
The short answer is yes, you can fold on your CPU and both GPUs, and there is a significant advantage to doing so.
I would recommend downloading and running the v7 client from the
main page. It's an all-in-one client that can manage all of your hardware from one location, as opposed to the various v6 clients, where you had to run one per piece of hardware. The default installation should set up one SMP slot and 2 GPU slots automatically, and v7 should acknowledge your GPUs right off the bat. The install guide is
here and the FAHControl guide is
here; FAHControl is the GUI used to configure and manage the client.
When the installer asks for your username/team information, you'll see a field for a passkey, which can be obtained
here. You don't need a passkey, but having a qualified one allows you to earn bonus points for turning in WUs quickly, and with that hardware the bonus points will be substantial assuming you're running near 24/7. As of right now only CPU-based WUs (SMP and uniprocessor) earn bonuses, but news yesterday indicated that GPU WUs will start earning bonuses in the near future (probably on the order of months, but that's just rather uninformed speculation on my part; the Pande Group never gives substantive ETAs). You have to successfully turn in 10 bonus-eligible WUs and maintain a >80% successful completion percentage to earn bonuses. A 2600k should qualify that passkey in a few days, and as long as your system is stable*, you should have no problem maintaining an 80% completion rate.
Regarding Crossfire, FAH does not use it to have multiple cards work on a single WU, as the latency involved in that link (and SLI, for that matter) is too high to be beneficial. But you don't need to disable it, as the client will happily run one GPU slot on each card.
There's one change I'd have you make to the v7 client's configuration. Once it's installed, pause the SMP slot** and change the view mode from Novice to either Advanced or Expert. After that, go to Configure -> Slots, highlight the SMP slot, hit Edit, change the CPUs field in the SMP area from -1 to 6, then hit OK and Save the changes, and restart the slot(s). The reason for this is that SMP work runs as fast as the slowest thread, and the amount of CPU time that an AMD GPU eats up while folding will interfere with the SMP slot and significantly slow it down. Leaving one thread free for each GPU will result in the SMP work getting done much faster since 6 threads running with no interference is much better than 8 running with major interference.
As a heads up, GPU folding does not usually mix well with other GPU-intensive tasks such as gaming. Unlike CPUs, there is no scheduling software for GPUs, so they have a lot of trouble handling concurrent strenuous tasks. If you're going to be gaming or something, it's recommended that you pause the GPU slots while doing that other task and restart them when you're done.
*If you haven't overclocked, you should be fine. If you have, note that being Prime95/<some other stress tester> stable does not mean you're folding stable, as most stress testing apps doesn't really stress the same modules that F@h does. You might want to run
StressCPU v2, as that runs the same Gromacs code that F@h uses and is a better indicator of folding stability.
**Either hit the big Pause button on top, which will pause every slot, or right-click the SMP slot in the Folding Slots window and select Pause to only pause that one