Allosteric sodium in the helix bundle of a G-protein-coupled receptor (GPCR) can modulate the receptor activation on the intracellular side. This phenomenon has confounded the GPCR community for decades. In this work, we present a theoretical model that reveals the mechanism of the allosteric modulation induced by sodium in a GPCR. This may provide us with novel therapeutic potential for a multitude of neurological diseases, including chronic pain and depression.
CPUs>=3
timeout 4days
deadline 8days
GRO_A4
credit: 3300
k-factor: 0.75
# atoms 11659 : 51822
# atoms 11660 : 52890
# atoms 11661 : 52887
GRO_A4 Projects 11659-11661 move to FAH
Moderators: Site Moderators, FAHC Science Team
Re: GRO_A4 Projects 11659-11661 moving to advanced
These projects are moved to FAH since no error reports.