Folding Forum

Right now there are a lot of things that are easily manipulatable through recombinant technology but we dare not for feared consequences. Right now there are human antibody libraries created by CDR shuffling that are pretty useful. I was wondering if there was any instance of folding at home studyin...

I've had it working with the wireless for a week now. I used a automated installer some guy made that sets up finstall and everything. It installs two clients on because hyperthreading makes it think it has two CPUs. I'm getting projects worth around 250-350 points on the regular linux clients. Runn...

through the death of windows that is. I installed ubuntu 7.10 on it. Right now I'm having a hell of time getting the wireless setup, screwing around NDISwrapper. I got that installed using synaptec, actually getting it to install the windows drivers is tough for a linux virgin like me. Anyway, this ...

Ok, I read the first article. It pretty interesting, who would have thought there would be knot functions. If you've been following this thread topoisomerase II might be of interest to you. The enzyme binds to DNA where it must be untangled it makes a double strand break, allowing a strand to pass t...

I've been posting a lot lately in this forum its just exciting that computational biology and chemistry is providing such potential for awesome breakthroughs, whether it be the human genome and its annotation or the biggest distributed computing project Foilding@home. Its pretty cool. I would think ...

Yes, x-ray crystallography is very complex and time consuming, and you have to be an expert in that to actually do it. Frankly I haven't one paper all the way through. I have read bits and pieces, and I will probably get to the wiki sooner or later. Some of the stuff in the peer reviewd articles is ...

By that I mean, is it just in the stages of continually perfecting algorithms to better model protein folding? Since right now the best structures would be in Swissprot and experimentally derived, and those are considered better. Or, are you starting to look at novel proteins relevent to research go...

Yes, modeling protein folding in silico does have the potential to make many a break through. If accurate it helps cut many corners in the research process and we might see patterns that we haven't seen before once this ramps up even further. Maybe I'll see if there is a peer reviewed article out th...

Hmm, sounds interesting I would have liked to read that.

An educated guess to the last question: The quotations of the articles citing knotted proteins mentioned that very few proteins are knotted that they have found. Enzymes are proteins most of the time (or RNA, or RNA-protein complexes, i.e. a ribozyme). So, just because those knotted proteins they ha...

Yeah, string theory isn't really applicable to protein folding. Like you don't build a bridge with general relativity, but I don't think you were implying that really. I didn't read the article yet but keep in mind that DNA forms a very consistent secondary structure (the 3 forms of double helices) ...

That is cool, thanks for posting the excerpt I didn't feel like reading through the paper plus the stuff I did read was a little over my head on the biochemistry and kinetics. Given the comparison between in silico and experimentally determined sturcture we can see that the in silico structure deter...

Ok, Protein folding overview: excuse me for the length Proteins are a series of amino acids linked together by something called a peptide bond. All 20 amino acids have the same basic structure required to form the peptide bond (an amino group and a carboxylic acid group) and an R group. The R group ...