Folding Forum

These projects are moved to FAH since no error reports.

Allosteric sodium in the helix bundle of a G-protein-coupled receptor (GPCR) can modulate the receptor activation on the intracellular side. This phenomenon has confounded the GPCR community for decades. In this work, we present a theoretical model that reveals the mechanism of the allosteric modula...

The heterotrimeric Gq proteins are molecular switches that perceive the signal from G-protein-coupled receptors (GPCRs) to regulate the physiological behaviors of its downstream protein-beta isoform of phospholipase C (beta-PLC). This pivotal role makes Gq proteins essential players in cardiac physi...

For this project, we are studying the switching of Gq proteins between "inactive" state and "active" state: The heterotrimeric Gq proteins are molecular switches that perceive the signal from G-protein-coupled receptors (GPCRs) to regulate the physiological behaviors of its downs...

For this project, we are studying the switching of Gq proteins between "inactive" state and "active" state: The heterotrimeric Gq proteins are molecular switches that perceive the signal from G-protein-coupled receptors (GPCRs) to regulate the physiological behaviors of its downs...

These two project are the extension of project 10188-9 viewtopic.php?f=66&t=27264&p=273230&hilit=10188#p273230 Credit: 408 Timeout: 8 days Deadline: 16 days This project aims to understand the dynamics of rhodopsin. Rhodopsin is the protein responsible for detecting light in the eye and ...

This project aims to understand the folding mechanisms of a fast-folding variant of the bacteriophage lambda-repressor. The lambda-repressor is responsible for the life-cycle of phage lambda by inhibiting transcription of the cro gene and simultaneously activating the cl gene. Detailed knowledge of ...

These projects are the following ups of project 10188-9 viewtopic.php?f=66&t=27264&p=273230&hilit=10188#p273230 Credit: 1100 Timeout: 8 days Deadline: 16 days CPUs 1,2 4,6,8,12 min core 2.2.7, min client 7.2.9 This project aims to understand the dynamics of rhodopsin. Rhodopsin is the pr...

These two projects are the extended simulations of our previous simulations about Opsin. These projects aim to understand the dynamics of rhodopsin. Rhodopsin is the protein responsible for detecting light in the eye and triggering a signaling cascade that ultimately results in an electrical stimulu...

For this project, we are studying the switching of Gq proteins between "inactive" state and "active" state: The heterotrimeric Gq proteins are molecular switches that perceive the signal from G-protein-coupled receptors (GPCRs) to regulate the physiological behaviors of its downs...